Glycyrrhizinate reduces portal hypertension in isolated perfused rat livers with chronic hepatitis

Figure 2 Glycyrrhizinate reduced portal hypertension in isolated portal perfuse rat liver with chronic hepatitis. A: Normal hepatic structure at d₀ (× 100); B: Hepatic degeneration at d₂₈ (× 100); C: Hepatic fibrosis at d₅₆ (× 100); D: Hepatic cirrhosis at d₈₄ (× 100); E: Inducible nitric oxide synthase (iNOS) were located at the hepatocyte (solid arrow) and scattered stellates (dashed arrow) at d₀ (× 400); F: iNOS were located at hepatocytes (solid arrow) and stellates (dashed arrow) in the lobules at d₂₈ (× 400); G: iNOS were located at stellates (dashed arrow) in the lobules and macrophages (solid arrow) outside of lobules at d₅₆ (× 400); H: iNOS were located at macrophages (solid arrow) outside of lobules and stellates (dashed arrow) at d₈₄ (× 400); I: Diammonium glycyrrhizinate (Gly) reducing portal hypertension at d₀; J: Gly reducing portal hypertension at d₂₈; K: Gly reducing portal hypertension at d₅₆; L: Gly reducing portal hypertension at d₈₄.