Overexpression of insulin-like growth factor-I receptor as a pertinent biomarker for hepatocytes malignant transformation

doi:10.3748/wjg.v19.i36.6084

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 28, 2013; 19(36): 6084-6092
Published online Sep 28, 2013. doi: 10.3748/wjg.v19.i36.6084

Table 3 Dynamic alteration of liver insulin-like growth factor-I receptor expression in hepatocarcinogenesis n (%)

Group	n	Positive	P value	IGF-IR intensity				Nemenyi test	P value
Group	n	Positive	P value	-	+	++	+++	Nemenyi test	P value
Control	12	0 (0.0)		12	0	0	0
Degeneration	18	9 (50.0)¹	0.004	9	4	4	1	13.716¹	< 0.050
Precancerosis	9	8 (88.9)¹	< 0.001	1	3	2	3	16.229¹	< 0.001
HCC	9	9 (100)¹	< 0.001	0	1	5	3	16.299¹	< 0.001

¹Compared with the control group by the Kruskal-Wallis test (HC = 25.5149, P < 0.001). IGF-IR: Insulin-like growth factor-I receptor; HCC: Hepatocellular carcinoma.

Citation: Yan XD, Yao M, Wang L, Zhang HJ, Yan MJ, Gu X, Shi Y, Chen J, Dong ZZ, Yao DF. Overexpression of insulin-like growth factor-I receptor as a pertinent biomarker for hepatocytes malignant transformation. World J Gastroenterol 2013; 19(36): 6084-6092
URL: https://www.wjgnet.com/1007-9327/full/v19/i36/6084.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i36.6084