Overexpression of insulin-like growth factor-I receptor as a pertinent biomarker for hepatocytes malignant transformation

doi:10.3748/wjg.v19.i36.6084

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Sep 28, 2013 (publication date) through Jul 27, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 28, 2013; 19(36): 6084-6092
Published online Sep 28, 2013. doi: 10.3748/wjg.v19.i36.6084

Table 2 Total RNA and insulin-like growth factor-I receptor mRNA expression in hepatocarcinogenesis n (%)

Group	n	Total RNA level			IGF-IR mRNA
Group	n	(μg/mg wet liver)	q	P value	Positive	P value
Control	12	1.58 ± 0.94			0 (0.0)
Degeneration	18	1.91 ± 0.60¹	1.177	0.249	11 (61.1)¹	< 0.001
Precancerosis	9	2.00 ± 0.21¹	1.308	0.206	9 (100)¹	< 0.001
HCC	9	2.86 ± 0.60¹	3.843	0.001	9 (100)¹	< 0.001

¹Compared with the control group. IGF-IR: Insulin-like growth factor-I receptor; HCC: Hepatocellular carcinoma.

Citation: Yan XD, Yao M, Wang L, Zhang HJ, Yan MJ, Gu X, Shi Y, Chen J, Dong ZZ, Yao DF. Overexpression of insulin-like growth factor-I receptor as a pertinent biomarker for hepatocytes malignant transformation. World J Gastroenterol 2013; 19(36): 6084-6092
URL: https://www.wjgnet.com/1007-9327/full/v19/i36/6084.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i36.6084