Liver metastasis is the only independent prognostic factor in AFP-producing gastric cancer

Table 4 Univariate and multivariate survival analyses in α-fetoprotein-producing gastric cancer patients

Factor	Univariate1	Multivariate2
	P value	HR	95%CI	P value
Sex
Male vs female	0.3574
Age (yr)
65 ≤vs < 65	0.0917
Location
U vs ML	0.4311
Macroscopic type
Type 1/2/3/4 vs Type 0-I/II/III	0.3422
Tumor size (mm)
40 ≤vs < 40	0.3539
Histological type
Undifferentiated vs Differentiated	0.0503
pT categories
T2/3/4 vs T1	0.1428
Venous invasion
Positive vs negative	0.6696
Lymphatic invasion
Positive vs negative	0.6188
pN categories
Positive vs negative	0.9855
Liver metastasis
Positive vs negative	0.0006	17.587	2.112-147.12	0.0081

¹The Kaplan-Meier method, and significance was determined by the log-rank test;

²Multivariate survival analysis was performed using Cox’s proportional hazard model.