In vitro effect of amoxicillin and clarithromycin on the 3&rsquo; region of cagA gene in Helicobacter pylori isolates

doi:10.3748/wjg.v19.i36.6044

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 28, 2013; 19(36): 6044-6054
Published online Sep 28, 2013. doi: 10.3748/wjg.v19.i36.6044

Table 2 Distribution of cagA genotypes (Glu-Pro-Ile-Tyr-Ala motifs) and vacA s and m among Helicobacter pylori isolates obtained from patients with chronic gastritis coming from a region of high risk for gastric cancer, according to profile of in vitro antibiotic resistance

Antibiotic resistance	Isolates	Patients (n = 13)	Genotype	Diagnosis	MIC	EPIYA motifs (molecular weight in pairs of bases)
Antibiotic resistance	Isolates	Patients (n = 13)	Genotype	Diagnosis	MIC	Baseline	0.25	0.5	1	2	4
Amoxicillin	Single	SV301	cagA+/vacA s1m1	NAG	4	495	495	495	495	495/200	-
		SV310	cagA+/vacA s1m1	NAG	2	495	495	495	495	-	-
		SV333	cagA+/vacA s1m1	NAG	2	495	495	595/495	595/495	-	-
		SV328	cagA+/vacA s1m1	IM	2	695/595/495	495/300/200	495	NA	-	-
		SV338	cagA+/vacA s1m1	NAG	2	595/495	NA²	NA	NA	-	-
	Mixed	SV316	cagA+/vacA s1m1 cagA-/vacA s1m1	NAG	> 4	495	NA	NA	595/495	495	NA
Clarithromycin	Single	SV336	cagA+/vacA s1m1	NAG	2	595	595	595	595	-	-
	Single	SV440	cagA+/vacA s2m2	NAG	> 4	595	595/495	595/495	NA	NA	NA
	Mixed	SV415	cagA+/vacA s1m1 cagA-/vacA s1m1	NAG	> 4	495	495	495	495	495	2NA
	Mixed	SV438	Undefined	IM	2	NA²	NA¹	NA¹	NA	-	-
		SV323	cagA+/vacA s1m1	MAG	2	495	NA	NA	495/200	-	-
		SV323	cagA+/vacA s1m1	MAG	4	495	NA²	NA²	NA²	NA²
Amoxicillin + Clarithromycin	Single	SV399	cagA+/vacA s1m1	MAG	2	495	NA	495	495	-	-
Amoxicillin + Clarithromycin		SV399	cagA+/vacA s1m1	MAG	2	495	495/200	NA	495	-	-
		SV433	cagA+/vacA s1m1	NAG	> 4	495	NA	1NA	495	595/495	200
		SV433	cagA+/vacA s1m1	NAG	> 4	495	495	495	495	495	495

¹Positive for empty-site PCR;

²Negative for EPIYA PCR, cagA-specific PCR and cag empty-site PCR. NA: Did not amplify; PCR: Polymerase chain reaction; EPIYA: Glu-Pro-Ile-Tyr-Ala; NAG: non-atrophic gastritis; MIC: Minimum inhibitory concentration; IM: Intestinal metaplasia; MAG: Multifocal atrophic gastritis without intestinal metaplasia.

Citation: Bustamante-Rengifo JA, Matta AJ, Pazos A, Bravo LE. In vitro effect of amoxicillin and clarithromycin on the 3’ region of cagA gene in Helicobacter pylori isolates. World J Gastroenterol 2013; 19(36): 6044-6054
URL: https://www.wjgnet.com/1007-9327/full/v19/i36/6044.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i36.6044