Disparities of conjugating protective enzyme activities in the colon of patients with adenomas and carcinomas

doi:10.3748/wjg.v19.i36.6020

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Sep 28, 2013 (publication date) through Jan 30, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 28, 2013; 19(36): 6020-6025
Published online Sep 28, 2013. doi: 10.3748/wjg.v19.i36.6020

Table 2 Enzyme activities of glutathione S-transferase and uridine glucuronosyltransferase in the normal colon mucosa of patients with adenoma and carcinoma (mean ± SD)

Enzyme activities	Adenomas (n = 28)	Carcinomas (n = 20)	P-value (F-test)
GST (nmol/mg per minute)
Transversum	225 ± 104 (19)	237 ± 72 (18)	0.1342
Sigmoid	265 ± 152 (27)	232 ± 78 (19)	0.0046
Combined	268 ± 152 (28)	241 ± 69 (20)	0.0007
UGT (pmol mg per minute)
Transversum	231 ± 269 (17)	159 ± 122 (16)	0.0015
Sigmoid	170 ± 158 (23)	144 ± 96 (17)	0.0456
Combined	197 ± 200 (27)	150 ± 86 (19)	0.0005

Number of enzyme assays given in brackets. GST: Glutathione S-transferase; UGT: Uridine glucuronosyltransferase.

Citation: Hoensch HP, Roelofs HM, Edler L, Kirch W, Peters WH. Disparities of conjugating protective enzyme activities in the colon of patients with adenomas and carcinomas. World J Gastroenterol 2013; 19(36): 6020-6025
URL: https://www.wjgnet.com/1007-9327/full/v19/i36/6020.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i36.6020