Aberrant TGF-β1 signaling contributes to the development of primary biliary cirrhosis in murine model

Figure 1 Histological features of the liver. A: Control mice; B-F: Mice model; B: Lymphocytic infiltration (red arrows) around the small bile ducts within the portal tracts at week 8; C: Bile plugs were seen in canaliculi at week 24; D: CK-7 expression in periportal proliferated bile ductile and intralobular hepatocytes; E: CD4⁺ lymphocytes infiltration; F: CD8⁺ lymphocytes infiltration (bar 10 μm).