A phase II study of paclitaxel and nedaplatin as front-line chemotherapy in Chinese patients with metastatic esophageal squamous cell carcinoma

Table 3 Adverse events assessment n (%)

Adverse event	NCI-CTC grade (n = 39)					Grade 3/4
	1	2	3	4	Any
Hematologic
Leucopenia	15 (25.6)	13 (33.3)	4 (10.3)	2 (5.1)	34 (87.2)	15.4%
Anemia	17 (43.6)	5 (12.8)	2 (5.1)	1 (2.6)	25 (64.1)	7.7%
Thrombocytopenia	11 (28.2)	5 (12.8)	2 (5.1)	0 (0.0)	18 (46.2)	5.1%
Nonhematologic
Gastrointestinal
Nausea	11 (28.2)	8 (20.5)	4 (10.3)	0 (0.0)	23 (59.0)	10.3%
Vomiting	10 (25.6)	6 (15.4)	2 (5.1)	0 (0.0)	18 (46.2)	5.1%
Diarrhea	6 (15.4)	0 (0.0)	0 (0.0)	0 (0.0)	6 (15.4)	0.0%
Stomatitis	2 (5.1)	1 (2.6)	0 (0.0)	0 (0.0)	3 (7.7)	0.0%
Hepatic
AST	2 (5.1)	0 (0.0)	0 (0.0)	0 (0.0)	2 (5.1)	0.0%
ALT	1 (2.6)	0 (0.0)	0 (0.0)	0 (0.0)	1 (2.6)	0.0%
Renal
Serum creatine	2 (5.1)	0	0 (0.0)	0 (0.0)	2 (5.1)	0.0%
Alopecia	3 (7.7)	9 (23.1)	0 (0.0)	0 (0.0)	12 (30.8)	0.0%
Myalgia	12 (30.8)	5 (12.8)	0 (0.0)	0 (0.0)	18 (43.6)	0.0%
Fatigue	20 (51.3)	2 (5.1)	0 (0.0)	0 (0.0)	22 (56.4)	0.0%
Neutropenia fever	0 (0.0)	0 (0.0)	1 (2.6)	0 (0.0)	1 (2.6)	2.6%

AST: Aspartate aminotransferase; ALT: Alanine aminotransferase.