Association between UCP3 gene polymorphisms and nonalcoholic fatty liver disease in Chinese children

doi:10.3748/wjg.v19.i35.5897

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 21, 2013; 19(35): 5897-5903
Published online Sep 21, 2013. doi: 10.3748/wjg.v19.i35.5897

Table 2 The genotypic distributions of the four loci in the UCP3 gene n (%)

		Genotypes			P value	Allele Frequency		P value
	n	Homozygous wild-type	Homozygous mutant-type	Heterozygous mutant-type	P value	Mutant-type	Wild-type	P value
rs1726745		GG	AA	AG		A	G
NAFLD	249	40 (16.1)	102 (41.0)	107 (43.0)	0.59	311 (62.4)	187 (37.6)	0.29
Controls	200	37 (18.5)	73 (36.5)	90 (45.0)	0.59	236 (59.0)	164 (41.0)	0.29
rs3781907		TT	CC	CT		C	T
NAFLD	239	87 (36.4)	42 (17.6)	110 (46.0)	0.23	194 (40.6)	284 (59.4)	0.19
Controls	198	57 (28.8)	37 (18.7)	104 (52.5)	0.23	178 (44.9)	218 (55.0)	0.19
rs11235972		GG	AA	AG		A	G
NAFLD	236	130 (55.1)	26 (11.0)	80 (33.9)	0.03	132 (28.0)	340 (72.0)	0.28
Controls	198	90 (45.5)	16 (8.0)	92 (46.5)	0.03	124 (31.3)	272 (68.7)	0.28
rs1800849		CC	TT	TC		T	C
NAFLD	249	133 (53.4)	25 (10.0)	91 (36.5)	0.14	141 (28.3)	357 (71.7)	0.54
Controls	199	92 (46.2)	16 (8.0)	91 (45.7)	0.14	123 (30.9)	275 (69.1)	0.54

NAFLD: Nonalcoholic fatty liver disease.

Citation: Xu YP, Liang L, Wang CL, Fu JF, Liu PN, Lv LQ, Zhu YM. Association between UCP3 gene polymorphisms and nonalcoholic fatty liver disease in Chinese children. World J Gastroenterol 2013; 19(35): 5897-5903
URL: https://www.wjgnet.com/1007-9327/full/v19/i35/5897.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i35.5897