Overlap of functional heartburn and gastroesophageal reflux disease with irritable bowel syndrome

Table 2 Prevalence of irritable bowel syndrome in gastroesophageal reflux disease/functional heartburn patients

GERD patients (n)	FH patients (n)	Diagnostic investigations of heartburn	IBS prevalence	IBS criteria	Diagnostic investigations of IBS	Authors
910	Not evaluated	Postal SQ	19%	Manning	Postal SQ	Kennedy et al[23]1
80	Not evaluated	SQ	36.7%-45.1%	Manning	SQ	Chey et al[40]2
34 (ERD)	Not evaluated	S, UE	36% (in ERD)	Manning	SQ	Nojkov et al[41]
67 (NERD)			35% (in NERD)
643	Not evaluated	SQ	42%	Rome I	SQ	Locke et al[42]
35	Not evaluated	SQ	71%	Rome I	SQ	Pimentel et al[43]
79	Not evaluated	SQ	3%	Rome I	SQ	Hu et al[25]1
457	Excluded	S, UE, OM, pH	49%	Rome I	SQ	Zimmerman et al[44]
79	Not evaluated	Phone SQ	13%	Rome I	Phone SQ	Cheung et al[12]1
326 (NERD)	Excluded	S, UE, pH	48.5%	Rome I	SQ	Hershcovici et al[45]
326 (NERD)	Excluded	S, UE, pH	49%	Rome I	SQ	Zimmerman et al[46]
41 (ERD)	Not evaluated	S, UE	48.7% (in ERD)	Rome I	S, SC, HE	Camacho et al[26]1
45 (NERD)			48.8% (in NERD)
3318	Not evaluated	SQ	36.7%-45.1%	Rome II	SQ	Bueno et al[47]2
102	Excluded	S, UE, OM, pH	32.4%	Rome II	SQ	Raftopoulos et al[48]
3318	Not evaluated	SQ	27%	Rome II	SQ	Guillemot et al[49]
263	Not evaluated	S, pH	35%	Rome II	SQ	De Vries et al[50]
111 (ERD)	Excluded	S, UE, OM, pH.	15.3% (in ERD)	Rome II	SQ	Wu et al[51]
113 (NERD)			44.2% (in NERD)
238	Not evaluated	SQ	60.9%	Rome II	SQ	Nasseri-Moghaddam et al[52]
67	Not evaluated	SQ	27%	Rome II	SQ	Lee et al[31]1
16	Not evaluated	SQ	50%	Rome II	SQ	Hori et al[32]1
92	Not evaluated	SQ	62%	Rome II	SQ	Rey et al[53]
102 (ERD)	Excluded	S, UE, OM, pH	20.6% (in ERD)	Rome II	SQ	Wu et al[54]
163 (NERD)			39.9% (in NERD)
411	Not evaluated	Postal SQ	20.2%	Rome III	Postal SQ	Jung et al[10]1
344	Not evaluated	SQ	51.7%	Rome III	SQ	Solhpour et al[55]
36/95 (ERD) 36/95 (NERD)	23/95	S, UE, OM, pH	17% (in ERD)	Rome III	SQ	Lee et al[56]
			23% (in NERD)
			39% (in FH)
207	Not evaluated	SQ	29.5%	Rome III	SQ	Kaji et al[36]1
286 (ERD)	Not evaluated	S, UE	11.2%	Rome III	SQ	Noh et al[57]
74 (NERD)			41.9%
2658	Not evaluated	S, UE	33.9%	Rome III	SQ	Yarandi et al[35]1
				Rome II
207	Not evaluated	SQ	29.5%	Rome III	SQ	Fujiwara et al[38]1
48/92 (NERD)	44/92	S, UE, OM22, MII-pH	39.6% (in NERD)	Rome III	SQ	Martinucci et al[39]12
			61.4% (in FH)
1181 (ERD) 694 (NERD)	Not evaluated	S, UE	12.7% (in ERD)	ReQuest	SQ	Mönnikes et al[58]
			18.3% (in NERD)
6810	Not evaluated	SQ	60%	ReQuest	SQ	Fass et al[59]2
257	Not evaluated	SQ	58%	ReQuest	SQ	Bardhan et al[60]

¹Articles listed in both tables 1 and 2;

²Abstract only (publication type).GERD: Gastroesophageal reflux disease; FH: Functional heartburn; IBS: Irritable bowel syndrome; S: Symptoms; SQ: Symptom questionnaire; PE: Physical examination; HE: Hematological examinations; BE: Barium enema; BC: Bacteriological culture; SC: Stool culture; BT: Lactose/lactulose breath test; AU: Abdominal ultrasonography; UE: Upper endoscopy; LE: Lower endoscopy; LEB: Lower endoscopy and biopsies; SBB: Small-bowel biopsies; Sg: Sigmoidoscopy; OM: Esophageal manometry; pH: pH-metry; MII-pH: pH impedance monitoring; ERD: Erosive reflux disease; NERD: Nonerosive reflux disease.