Polymorphism in the interleukin-17A promoter contributes to gastric cancer

Table 3 Effect of G-197A polymorphism on gastric cancer development n (%)

	GA + AA	GG	OR	95%CI	P-value2
Age
< 50 yr	18 (17.1)	4 (7.1)	2.7	0.8-8.4	0.09
≥ 50 yr	87 (82.9)	52 (92.9)
Gender
Male	51 (48.6)	21 (37.5)	1.6	0.8-3.05	0.19
Female	54 (51.4)	35 (62.5)
H. pylori+	65 (61.9)	33 (58.9)	0.88	0.45-1.71	0.74
H. pylori-	40 (38.1)	23 (41.1)
TNM stage1
I-II	22 (55)	6 (16.2)	6.3	2.2-18.5	0.001
III-IV	18 (45)	31 (83.8)
Tumor differentiation
Well	25 (23.8)	9 (16.1)	1.003
Moderate	57 (54.3)	35 (62.5)	0.56	0.24-1.34	0.19
Poor	23 (21.9)	12 (21.4)	0.66	0.23-1.86	0.43

¹Data presented for 77 patients;

²All comparisons between categorical variables were made using a two-sided χ² test;

³Used as reference for tumor differentiation analyses. Values in parentheses indicate the percentage. H. pylori: Helicobacter pylori; TNM: Tumor, node, metastasis.