Polymorphism in the interleukin-17A promoter contributes to gastric cancer

Table 2 Frequency of the distribution of the G-197A (rs2275913) polymorphism of the interleukin-17A gene in gastric cancer patients and healthy controls n (%)

Genotype	Cancer (n = 161)	Controls (n = 171)	OR	CI	P-value1
GG	56 (34.8)	78 (45.6)	1.002
GA	61 (37.9)	72 (42.1)	1.2	0.73-1.91	0.53
AA	44 (27.3)	21 (12.3)	2.92	1.56-5.4	0.001
G allele	173 (53.7)	228 (66.7)	1.002
A allele	149 (46.3)	114 (33.3)	1.72	1.26-2.36	0.001
A allele carriage (AA + GA vs GG)	105 (64.2)	93 (54.4)	1.57	1.01-2.45	0.04

Genotype frequencies are indicated in absolute values, with the percentage in parentheses. G allele and A allele indicates the total number of each individual allele within each group.

¹Two-sided χ²-test;

²The first allele or genotype is considered as the reference for this analysis. OR: Odds ratio.