Lactic acidosis during telbivudine treatment for HBV: A case report and literature review

Figure 4 Histopathology of muscle biopsy specimens showed mitochondrial toxicity. A: Many regenerating and necrotic muscle fibers, mild nuclear proliferation and necrosis around muscle fibers (HE, magnification × 200); B: Part of muscle fibers filled with fatty droplets (HE, magnification × 400); C: Ragged red fibers under envelope of shrinking muscle cells (modified Gomori trichrome stain, magnification × 200); D: The figure revealed the structural disorders of mitochondria. The myocytes different in size; Type I and Type II muscle fibers showed mosaic arrangement (nicotinamide-adenine dinucleotid, magnification × 200).