Fucoidan enhances intestinal barrier function by upregulating the expression of claudin-1

Figure 1 Fucoidan directly enhanced intestinal epithelial barrier function. Polarized Caco-2 cell monolayers were incubated in the presence or absence of fucoidan (2.5 mg/mL) for 24 h. Changes in intestinal epithelial barrier function were monitored by measuring the trans-epithelial resistance (TER). The data are expressed as the means ± SEM of 5 independent experiments. ^aP < 0.05 compared with control (Student’s t test).