Propofol induces apoptosis and increases gemcitabine sensitivity in pancreatic cancer cells in vitro by inhibition of nuclear factor-κB activity

Figure 6 Propofol abrogates gemcitabine-induced nuclear factor-κB in MIA-PaCa-2 cells. A: MIA-PaCa-2 cells were exposed to 10-100 μmol/L gemcitabine for 72 h. Nuclear extracts were analyzed by electrophoretic mobility shift assay (EMSA); B: Propofol abrogated gemcitabine induced nuclear factor-κB (NF-κB) in MIA-PaCa-2 cells exposed to 100 μmol/L/mL propofol for 24 h followed by incubation with 100 μmol/L gemcitabine. Nuclear extracts were harvested at 72 h and analyzed by EMSA. Propofol pretreatment downregulated gemcitabine-induced NF-κB with 100 μmol/L gemcitabine.