Impact of intraoperative blood loss on survival after curative resection for gastric cancer

Table 2 Survival analysis of all patients with gastric cancer

Characteristics	n (%)	5-yr OS	Univariate analysis		Multivariate analysis
			χ2	P value	HR (95%CI)	P value
Gender			1.609	0.205
Male	607 (71.8)	42.20%
Female	238 (28.2)	47.10%
Age (yr)			21.037	< 0.001
≤ 65	489 (57.9)	50.10%			1 (ref)
> 65	356 (42.1)	34.60%			1.372 (1.140-1.652)	0.001
Tumor location			26.417	< 0.001
Lower 1/3	367 (43.4)	50.10%			1 (ref)
Middle 1/3	83 (9.8)	45.80%			0.978 (0.680-1.407)	0.905
Upper 1/3	296 (35.0)	39.50%			0.931 (0.741-1.169)	0.538
2/3 or more	99 (11.7)	29.30%			1.149 (0.832-1.586)	0.398
Tumor size			58.693	< 0.001
< 5 cm	348 (41.2)	57.80%			1 (ref)
≥ 5 cm	497 (58.8)	33.60%			1.411 (1.152-1.730)	0.001
Borrmann type			13.517	< 0.001
I/II	355 (42.0)	50.40%			1 (ref)
III/IV	490 (58.0)	38.60%			1.285 (1.062-1.556)	0.010
Histology			6.783	0.009
Differentiated	281 (33.3)	49.80%			1 (ref)
Undifferentiated	564 (66.7)	40.40%			1.151 (0.939-1.412)	0.176
Extranodal metastasis			52.773	< 0.001
Negative	701 (83.0)	47.50%			1 (ref)
Positive	144 (17.0)	24.30%			1.543 (1.236-1.925)	< 0.001
TNM stage			147.103	< 0.001
I	96 (11.4)	82.30%			1 (ref)
II	269 (31.8)	58.40%			2.253 (1.362-3.727)	0.002
III	480 (56.8)	27.50%			4.736 (2.898-7.740)	< 0.001
Chemotherapy			10.999	0.001
Yes	237 (28.0)	50.60%			1 (ref)
No	608 (72.0)	40.80%			1.357 (1.093-1.684)	0.006
Extent of lymphadenectomy			6.668	0.010
D2 and D2+	397 (47.0)	48.40%			1 (ref)
D1	448 (53.0)	39.30%			1.372 (1.126-1.671)	0.002
Type of gastrectomy			21.400	< 0.001
Subtotal	653 (77.3)	47.00%			1 (ref)
Total	192 (22.7)	31.80%			1.102 (0.849-1.430)	0.466
Combined organ resection			10.310	0.001
No	778 (92.1)	44.60%			1 (ref)
Yes	67 (7.9)	31.30%			1.116 (0.811-1.536)	0.501
Intraoperative blood loss			29.175	< 0.001
< 200 mL	383 (45.3)	51.20%			1 (ref)
200-400 mL	398 (47.1)	39.40%			1.242 (1.017-1.516)	0.033
> 400 mL	64 (7.6)	23.40%			1.590 (1.140-2.217)	0.006
Perioperative transfusion			6.145	0.013
No	634 (75.0)	45.70%			1 (ref)
Yes	211 (25.0)	37.00%			0.962 (0.748-1.180)	0.708
Postoperative complications			28.320	< 0.001
Absent	782 (92.5)	44.90%			1 (ref)
Present	63 (7.5)	27.00%			2.096 (1.525-2.881)	< 0.001

OS: Overall survival; TNM: Tumour-node-metastasis.