Proposal of new classification for postoperative patients with hepatocellular carcinoma based on tumor growth characteristics

Table 2 Analysis of factors affecting survival

	Death/all cases	Median survival time (95%CI)	P value
Age (yr)			0.612
≤ 60	165/208	19 (13.470-24.530)
> 60	63/80	23 (15.988-30.012)
Gender			0.605
Male	36/49	20 (6.283-33.717)
Female	193/239	20 (15.131-24.869)
Tumor size (cm)			< 0.001
≤ 5	67/105	34 (17.568-50.432)
5 < size ≤ 10	107/125	17 (8.965-25.035)
> 10	55/58	8 (4.890-11.110)
Tumor status			< 0.001
T1	90/126	33 (24.933-41.067)
T2	14/22	25 (0.000-73.264)
T3a	26/31	15 (5.184-24.816)
T3b	24/27	8 (5.470-10.530)
T4	75/82	12 (7.905-16.095)
Regional lymph node metastasis			< 0.001
No	205/264	22 (16.882-27.118)
Yes	24/24	8 (3.999-12.001)
Distant metastasis			< 0.001
No	217/276	22 (17.691-26.309)
Yes	12/12	4 (2.303-5.697)
Child-Pugh score			< 0.001
A	203/260	23 (18.485-27.515)
B	26/28	7 (2.851-11.149)
AFP (ng/mL)			< 0.001
≤ 200	118/161	28 (21.162-34.838)
> 200	102/118	12 (8.198-15.802)
Expansive growth and invasive growth			< 0.001
Single tumor	103/143	33 (24.408-41.592)
Multiple tumors	18/25	25 (8.680-41.320)
Satellite nodules (including perforation tumor encapsulation)	18/22	13 (10.242-15.758)
Nodules fusion (including diffuse growth which lack tumor encapsulation)	16/18	12 (3.684-20.316)
Direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum	74/80	12 (7.956-16.044)
Disseminative growth			< 0.001
Without vascular or regional lymph node involvement	155/210	28 (21.928-34.072)
Vascular involvement	42/46	8 (4.979-11.021)
Regional lymph node involvement	21/21	10 (4.019-15.981)
Distant metastasis	12/12	4 (2.303-5.697)
EID stage			< 0.001
I	96/140	36 (27.626-44.374)
II	84/99	16 (11.450-20.550)
III	38/38	8 (4.375-11.625)
IV	11/11	5 (3.436-6.564)
TNM stage			< 0.001
I	84/119	35 (26.448-43.552)
II	14/22	25 (0.000-73.264)
IIIA	19/24	16 (2.557-29.443)
IIIB	22/25	8 (1.880-14.120)
IIIC	58/66	15 (10.033-19.967)
IVA	21/21	10 (4.019-15.981)
IVB	11/11	5 (3.436-6.564)

AFP: Alpha-fetoprotein; EID: Expansive-Invasive-Disseminative growth; TNM: Tumor-node-metastasis.