Biliary phosphatidylcholine and lysophosphatidylcholine profiles in sclerosing cholangitis

Table 4 Molar percentages of phosphatidylcholine and lysophosphatidylcholine species in bile from four patient groups

	Molecular weight (Da)	Controls (n = 11)	PSC (n = 14)	SSC (n = 10)	CCC ± PSC (n = 6)	P value
PC molecular species
32:1	732	2.8 ± 0.5	3.3 ± 0.4	9.2 ± 3.9	4.2 ± 0.7	0.036, controls vs SSCa
32:0	734	1.1 ± 0.1	1.4 ± 0.2	3.6 ± 1.2	1.5 ± 0.2	0.029, controls vs SSCa
34:3	756	2.2 ± 0.3	2.7 ± 0.2	2.7 ± 0.4	2.0 ± 0.4	0.19
34:2	758	33.7 ± 1.1	28.5 ± 0.7	25.8 ± 3.1	29.8 ± 0.2	0.017, controls vs PSCc
34:1	760	22.8 ± 0.9	22.1 ± 0.7	22.2 ± 0.9	24.1 ± 1.3	0.55
36:4	782	10.5 ± 0.6	10.3 ± 0.7	10.1 ± 1.8	8.6 ± 0.5	0.24
36:3	784	8.8 ± 0.3	10.0 ± 0.4	8.4 ± 0.8	7.1 ± 0.7	0.013, CCC vs PSCc
36:2	786	7.3 ± 0.4	9.0 ± 0.6	8.1 ± 0.9	9.3 ± 0.9	0.13
36:1	788	3.3 ± 0.3	3.5 ± 0.3	3.7 ± 0.4	3.2 ± 0.4	0.65
38:7	804	0.8 ± 0.2	0.9 ± 0.3	0.4 ± 0.3	0.2 ± 0.1	0.10
38:6	806	2.6 ± 0.2	3.3 ± 0.3	2.5 ± 0.5	6.3 ± 2.5	0.05
38:5	808	2.1 ± 0.1	2.7 ± 0.3	1.6 ± 0.4	2.0 ± 0.3	0.09
38:4	810	1.9 ± 0.2	2.3 ± 0.3	1.8 ± 0.4	1.9 ± 0.3	0.51
LPC molecular species
16:0	496	59.2 ± 7.0	56.0 ± 5.8	85.0 ± 5.2	58.9 ± 7.0	0.05, controls vs SSCa, PSC vs SSCb
18:2	520	21.2 ± 6.0	12.6 ± 4.0	0.9 ± 0.9	30.0 ± 9.0	0.02, stones vs SSCa, CCC vs SSCb
18:1	522	9.7 ± 2.3	16.0 ± 2.9	7.4 ± 2.6	4.0 ± 4.0	0.08
18:0	524	9.9 ± 5.4	15.5 ± 2.3	6.8 ± 2.2	7.2 ± 7.2	0.06

^aP < 0.05,

^bP < 0.01 vs secondary sclerosing cholangitis (SSC) group;

^cP < 0.05 vs primary sclerosing cholangitis (PSC). CCC: Cholangiocellular carcinoma; PC: Phosphatidylcholine; LPC: Lysophosphatidylcholine.