Systematic review and meta-analysis of laparoscopy-assisted and open total gastrectomy for gastric cancer

Table 2 Results of meta-analysis

Outcome	No. of study	Sample size		Heterogeneity (P, I2)	Overall effect size	95%CI of overall effect	P value
		LATG	OTG
Operating time (min)	9	436	785	< 0.001, 94%	WMD = 57.68	30.48-84.88	< 0.001
Blood loss	7	309	404	< 0.001, 95%	SMD = -1.71	-2.48 - -0.94	< 0.001
Retrieved lymph nodes	9	436	785	0.09, 41%	WMD = -1.41	-3.15 - 0.32	0.11
Proximal margin (cm)	2	163	475	1.00, 0%	WMD = -0.40	-0.82 - 0.02	0.06
Distal margin (cm)	2	163	475	0.67, 0%	WMD = 0.46	-0.40 - 1.32	0.29
Analgesics given	4	221	300	< 0.001, 93%	SMD = -0.86	-1.62 - -0.11	0.02
Duration of fever (d)	2	112	138	0.47, 0%	WMD = -1.58	-1.80 - -1.37	< 0.001
Time to first flatus (d)	7	316	419	< 0.001, 91%	WMD = -0.76	-1.22 - -0.30	0.001
Time to oral intake (d)	4	161	257	0.04, 63%	WMD = -0.81	-1.26 - -0.35	< 0.001
Hospital stay (d)	8	354	691	0.02, 56%	WMD = -2.67	-3.96 - -1.38	< 0.001
Overall complications	9	436	785	0.10, 40%	RR = 0.79	0.61-1.02	0.07
Surgical complications	9	436	785	0.42, 2%	RR = 0.83	0.64-1.08	0.16
Medical complications	7	343	614	0.70, 0%	RR = 0.41	0.19-0.90	0.03
Mortality	4	229	490	0.66, 0%	RR = 0.72	0.20-2.57	0.61

WMD: Weighted mean difference; SMD: Standard mean difference; LATG: Laparoscopy-assisted total gastrectomy; OTG: Open total gastrectomy.