Somatic molecular changes and histo-pathological features of colorectal cancer in Tunisia

doi:10.3748/wjg.v19.i32.5286

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 28, 2013; 19(32): 5286-5294
Published online Aug 28, 2013. doi: 10.3748/wjg.v19.i32.5286

Table 3 Comparison of the somatic phenotype and genotype as a function of the patient’s clinical characteristics

	MSI (n = 10)	KRAS mutations (n = 16)	TP53 mutations (n = 28)	TP53 overexpression (n = 21)	MUC5AC overexpression (n = 15)
Mean age at diagnosis (range), yr	45 (18-72)	51.5 (18-85)	48.5 (18-79)	49.5 (24-75)	50 (24-76)
Sex
Males	80.00%	75.00%	57.10%	52.40%	66.70%
Females	20.00%	25.00%	42.90%	47.60%	33.30%
Tumor site¹
Proximal	50.00%	18.80%	21.40%	28.60%	33.30%
Distal	50.00%	81.30%	78.60%	71.40%	66.70%
TNM stage²
I	10.00%	6.30%	0.00%	0.00%	0.00%
II	40.00%	43.80%	48.10%	38.10%	40.00%
III	50.00%	50.00%	44.40%	47.60%	53.30%
IV	0.00%	0.00%	7.40%	9.50%	6.70%

¹Proximal, right colon; distal, left colon + rectum;

²Tumor, node, metastasis (TNM) stage was unknown for one patient; MSI: Microsatellite instability; MUC: Mucin.

Citation: Aissi S, Buisine MP, Zerimech F, Kourda N, Moussa A, Manai M, Porchet N. Somatic molecular changes and histo-pathological features of colorectal cancer in Tunisia. World J Gastroenterol 2013; 19(32): 5286-5294
URL: https://www.wjgnet.com/1007-9327/full/v19/i32/5286.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i32.5286