Risk factors for local recurrence following neoadjuvant chemoradiotherapy for rectal cancers

Table 3 Relationship between tumor response and local recurrence rate n (%)

Ref.	No. of patients	Neoadjuvant therapy regimen		No. of LR
		Radiotherapy (Gy)	Chemotherapy	pCR LR/total	Non-pCR LR/total
Gavioli et al[31]	139	50	5-Fu	0/25 (0.0)	8/114 (7.0)
Stipa et al[57]	200	50	5-Fu	0/60 (0.0)	6/140 (4.3)
Hughes et al[71]	130	45	5-Fu	0/23 (0.0)	23/107 (17.7)
Kim et al[82]	114	50.4	5-Fu	0/10 (0.0)	17/104 (16.3)
Kuo et al[83]	248	50	5-Fu	2/36 (5.6)	66/212 (31.1)
Chan et al[84]	128	50	5-Fu	0/32 (0.0)	24/96 (18.4)
García-Aguilar et al[86]	168	40-65	5-Fu	0/21 (0.0)	7/147 (5)
Wheeler et al[87]	63	45-50	5-Fu	1/29 (3.4)	8/34 (23.5)
Theodoropoulos et al[88]	88	45	5-Fu	0/16 (0.0)	3/72 (4.2)
Total	1278			3/252 (1.2)	162/1026 (15.8)

LR: Local recurrence; pCR: Pathologic complete remission; 5-Fu: 5-fluorouracil.