Review
Copyright ©2013 Baishideng Publishing Group Co.
World J Gastroenterol. Aug 28, 2013; 19(32): 5212-5226
Published online Aug 28, 2013. doi: 10.3748/wjg.v19.i32.5212
Table 2 MicroRNAs as potential diagnostics and therapeutics for hepatocellular carcinoma
miRNAsDetailRelevance
miR-2214.8 fold higher in HCC patients, positively correlates with cirrhosis, tumour size and stage. Negatively correlates with overall survivalPotential circulating biomarker
miR-199aReduced and significantly associated with HCCPotential circulating biomarker
miR-16Reduced and significantly associated with HCCPotential circulating biomarker
miR-26Low levels associated with high IL-6 and shorter survivalPotential biomarker to assess prognosis of HCC
miR-375Lower than normal levels associated with β-catenin mutationPotential for HCC classification system, determine treatment allocation
miR-107Reduced levels associated with HFN 1αPotential for HCC classification system, use to determine treatment allocation
miR-122Expression inhibited using Miravirsen LNA-modified oligonucleotidesDirect effect in chimpanzee model in reducing HCV replication and viraemia
miR-196Selective target for interventionImplications for treatment
miR-26aDeliverable to HCC sites using adeno-associated virus serotype 8Decreased proliferation and induced tumour-specific apoptosis
miR-124Induces tumour-specific apoptosisPrevents and suppresses HCV development in murine model