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©2013 Baishideng Publishing Group Co.
World J Gastroenterol. Aug 28, 2013; 19(32): 5212-5226
Published online Aug 28, 2013. doi: 10.3748/wjg.v19.i32.5212
Published online Aug 28, 2013. doi: 10.3748/wjg.v19.i32.5212
miRNAs | Detail | Relevance |
miR-221 | 4.8 fold higher in HCC patients, positively correlates with cirrhosis, tumour size and stage. Negatively correlates with overall survival | Potential circulating biomarker |
miR-199a | Reduced and significantly associated with HCC | Potential circulating biomarker |
miR-16 | Reduced and significantly associated with HCC | Potential circulating biomarker |
miR-26 | Low levels associated with high IL-6 and shorter survival | Potential biomarker to assess prognosis of HCC |
miR-375 | Lower than normal levels associated with β-catenin mutation | Potential for HCC classification system, determine treatment allocation |
miR-107 | Reduced levels associated with HFN 1α | Potential for HCC classification system, use to determine treatment allocation |
miR-122 | Expression inhibited using Miravirsen LNA-modified oligonucleotides | Direct effect in chimpanzee model in reducing HCV replication and viraemia |
miR-196 | Selective target for intervention | Implications for treatment |
miR-26a | Deliverable to HCC sites using adeno-associated virus serotype 8 | Decreased proliferation and induced tumour-specific apoptosis |
miR-124 | Induces tumour-specific apoptosis | Prevents and suppresses HCV development in murine model |
- Citation: Greene CM, Varley RB, Lawless MW. MicroRNAs and liver cancer associated with iron overload: Therapeutic targets unravelled. World J Gastroenterol 2013; 19(32): 5212-5226
- URL: https://www.wjgnet.com/1007-9327/full/v19/i32/5212.htm
- DOI: https://dx.doi.org/10.3748/wjg.v19.i32.5212