MicroRNAs and liver cancer associated with iron overload: Therapeutic targets unravelled

doi:10.3748/wjg.v19.i32.5212

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 19, Issue 32

This Article

Academic Content and Language Evaluation of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (7967)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-1) series, Tables (1-2) series.

Item

Count

PDF

653

HTML

5095

Figures (1-1)

223

Tables (1-2)

205

Sum=6176

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

983

Download

808

Sum=1791

Aug 28, 2013 (publication date) through Nov 8, 2024

Times Cited of This Article

Times Cited (45)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Review

World J Gastroenterol. Aug 28, 2013; 19(32): 5212-5226
Published online Aug 28, 2013. doi: 10.3748/wjg.v19.i32.5212

Table 1 MicroRNAs with a role in hepatocellular carcinoma

miRNAs	Function	Outcomes
miR-22	Predicted to bind iron-bound transferrin receptor (TfR1)	Targets TfR1, DMT1 expression thereby inhibiting cell cycle progression and growth
miR-200a
miR-320
miR-200b	Targets ferritin heteropolymers (FtH1, FtL)	Decreased miR-200b linked with enhanced cancer aggressiveness via increased iron indices
miR-122	Targets HFE, hemojuvelin, BMPr1a, BMP/SMAD signalling, hepcidin	Control of systemic iron homeostasis. Decreased miR-122 corresponds to decreased HFE and hemojuvelin expression. This correlates with increased hepcidin expression

HCC: Hepatocellular carcinoma; miR/miRNA: MicroRNA; DMT: Divalent metal transporter; HFE: Human haemochromatosis; BMP: Bone morphogenetic protein; FtH: Ferritin heavy; FtL: Ferritin light.

Citation: Greene CM, Varley RB, Lawless MW. MicroRNAs and liver cancer associated with iron overload: Therapeutic targets unravelled. World J Gastroenterol 2013; 19(32): 5212-5226
URL: https://www.wjgnet.com/1007-9327/full/v19/i32/5212.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i32.5212