Isolated splenic metastases from gastric carcinoma: A case report and literature review

Table 1 Summary of patients with isolated splenic metastasis from gastric carcinoma treated by splenectomy

No.	Source	Gender/age (yr)	Primary gastric carcinoma		Splenic metastasis			CT appearance	Survival time (mo)/status/tumor dissemination
			Location1	Histology2	Interval3(mo)	Other involvement	Suggested route
1	Takebayashi et al[10]	F/64	U, M	Por, T3, n1, M1	0	LNs	Lymphatic	NS	3/dead/lung
2	Fujita et al[11]	F/75	R	Tub, T4, n3, M1	0	LNs	Hematogenous	NS	NS
3	Mori et al[12]	M/49	R	Tub, T3, n3, M1	0	LNs	Hematogenous	NS	12/alive/NS
4	Okuno et al[13]	M/56	U, M	Por, T3, n2, M1	0	LNs and peritoneum	Lymphatic	NS	1/dead/peritoneum, bone, pancreas, adrenal, liver
5	Sakamoto et al[14]	M/67	U, M	Tub, T4, n2, M1	0	LNs	Hematogenous	NS	8/dead/liver
6	Ishida et al[15]	M/65	U	Por, T2, n2, M1	0	LNs	NS	NS	5/dead/tumor embolism of portal vein
7	Lu et al[16]	M/59	U	Hepatoid AC, T4	0	LNs	NS	Heterogenous low-density lesions	18/alive/liver
8	Ikeda et al[17]	M/57	U	Por, T3, n1, M0	17	None	NS	NS	15/alive/ NS
9	Shirai et al[18]	M/63	M	Pap, T1, n0, M0	33	None	Hematogenous	NS	20/alive/ NS
10	Tatsusawa et al[19]	M/54	M	Tub, T2, n2, M0	102	None	Hematogenous	NS	NS
11	Takahashi et al[20]	M/64	L	Tub, T2, n3, M0	16	None	Hematogenous	NS	7/dead/liver, lung
12	Opocher et al[4]	F/76	L	Tub, T2, N0, M0	57	None	Hematogenous	Round cystic area with fluid content	13/alive/none
13	Opocher et al[4]	M/66	NS	Por, T2, N1, M0	36	None	Hematogenous	NS	14/alive/none
14	Williams et al[5]	M/69	U	AC	43	None	NS	Soft tissue mass with cacification	NS
15	Yamanouchi et al[8]	M/69	L	Tub, T2, N1, M0	48	None	Hematogenous?	Low-density area	40/dead/liver, peritoneum
16	Sunitsch et al[21]	F/80	L, R	Por, T1, N0, M0;	37	None	NS	NS	NS
				tp, T1, N0, M0
17	Kawasaki et al[22]	M/76	U	Pap, T1, N1, M0	12	None	Hematogenous?	Low-density lesion	24/alive/none
18	Zhou et al[23]	M/76	U	Tub	36	None	NS	NS	30/alive/none

¹U, M, and L: Indicate the upper, middle, and lower thirds of the stomach, respectively; R: Residual stomach;

²Por: Poorly differentiated adenocarcinoma; tub: Tubular adenocarcinoma; pap: Papillary adenocarcinoma; tp: Tubulopapillary adenocarcinoma; AC: Adenocarcinoma; T1: Tumor invades lamina propria, muscularis mucosae or submucosa; T2: Tumor invades muscularis propria; T3: Tumor penetrates subserosal connective tissue without invasion of visceral peritoneum or adjacent structures; T4: Tumor invades serosa (visceral peritoneum) or adjacent structures[1]; n: n0 indicates no evidence of lymph node metastasis; n1, n2, and n3 indicate metastasis to the groups 1, 2, and 3 lymph nodes, respectively, according to the Japanese Classification of Gastric Carcinoma[24]; N: N0: No regional lymph node metastasis; N1, N2 and N3 indicate metastasis in 1-2, 3-6, 7 or more regional lymph nodes; M: M0: No distant metastasis; M1: Distant metastasis;

³Interval: Interval from the detection of primary gastric carcinoma to the detection of the splenic secondary tumor. 0 indicates the the splenic secondary tumor detected at the same time as the primary tumor. LNs: Lymph nodes; CT: Computed tomography; NS: Not specified.