HMGB1 gene polymorphisms in patients with chronic hepatitis B virus infection

Table 2 Association between high mobility group box chromosomal protein 1 (1176G/C) single nucleotide polymorphism and hepatitis B virus infected subgroups

Subgroup	Dominant model		Recessive model		Codominant model
	P	OR (95%CI)	P	OR (95%CI)	P	OR (95%CI)
LC/CHB	0.075	0.533 (0.267-1.065)	0.945	0.988 (0.701-1.392)	0.120	0.844 (0.682-1.045)
LC/SHB	0.183	0.508 (0.188-1.376)	0.747	1.075 (0.693-1.669)	0.326	0.872 (0.664-1.146)
LC/AsC	0.168	2.320 (0.702-7.672)	0.108	1.572 (0.906-2.728)	0.011	1.571 (1.108-2.227)
AsC/SHB	0.473	1.616 (0.436-5.999)	0.489	1.204 (0.711-2.040)	0.206	1.254 (0.883-1.782)
AsC/CHB	0.238	1.660 (0.716-3.851)	0.052	1.389 (0.997-1.935)	0.007	1.354 (1.085-1.689)
SHB/CHB	0.916	1.050 (0.425-2.592)	0.474	1.137 (0.800-1.614)	0.462	1.090 (0.866-1.371)
SHB + LC/CHB + AsC	0.362	0.760 (0.421-1.371)	0.824	0.971 (0.747-1.262)	0.316	0.918 (0.777-1.085)
AsC/CHB + SHB + LC	0.330	1.505 (0.662-3.421)	0.044	1.401 (1.010-1.944)	0.010	1.329 (1.070-1.651)
AsC/CHB + LC	0.256	1.619 (0.704-3.721)	0.043	1.406 (1.011-1.956)	0.007	1.355 (1.088-1.687)

The association was analyzed by logistic regression analysis with adjustment for covariates, including age, sex, and alcohol consumption. Dominant model: GG + GC/CC, recessive model: GG/GC + CC, codominant model: GG/GC/CC; P and OR values were calculated by logistic regression. AsC: Asymptomatic carrier; AHB: Acute hepatitis B; CHB: Chronic hepatitis B; SHB: Severe hepatitis B; LC: Liver cirrhosis; OR: Odds ratio.