HMGB1 gene polymorphisms in patients with chronic hepatitis B virus infection

Table 1 High mobility group box chromosomal protein 1 polymorphism (1176G/C) between various clinical subgroups infected with hepatitis B virus

	Sex	Age (yr)	Genotype			Allele frequency
	(M/F)	(mean ± SD)	GG	CC	GC	G	C
AsC (n = 199)	116/83	34.762 ± 11.282	107	9	83	0.7462	0.2538
AHB (n = 15)	11/4	30.201 ± 10.221	9	1	5
CHB (n = 929)	730/199	34.312 ± 11.549	572	33	324	0.6530	0.3470
SHB (n = 157)	129/28	39.989 ± 11.792	91	6	60	0.7707	0.2293
LC (n = 175)	142/33	41.950 ± 11.437	104	13	58	0.7600	0.2300
HCC (n = 20)	14/6	49.256 ± 12.232	10	1	9
LC + CHB (n = 1104)	872/232	35.461 ± 11.642	676	46	382	0.7853	0.2147
LC + CHB + SHB (n = 1261)	1001/260	36.001 ± 11.852	767	52	442	0.7835	0.2165

There was age difference in any two subgroups except between AsC and CHB, P < 0.05; There was sex difference between AsC and any other subgroups, P < 0.05; AsC: Asymptomatic carrier; AHB: Acute hepatitis B; CHB: Chronic hepatitis B; SHB: Severe hepatitis B; LC: Liver cirrhosis; HCC: Hepatocellular carcinoma.