Rikkunshito improves globus sensation in patients with proton-pump inhibitor-refractory laryngopharyngeal reflux

Table 3 Gastrointestinal symptom rating scale scores after 4 wk treatments of rikkunshito with or without proton-pump inhibitor

	Week	Rikkunshito (mean ± SD)	Test1P value	Rikkunshito + PPI (mean ± SD)	Test1P value	Test2P value
Overall scores	-2	2.25 ± 1.06	0.232	2.19 ± 0.73	0.375	1.000
	0	2.12 ± 0.85	-	1.96 ± 0.50	-	0.778
	4	1.83 ± 0.84	0.148	1.73 ± 0.37	0.195	0.736
Subscale scores
Reflux syndrome	-2	2.25 ± 1.06	0.055	2.79 ± 0.91	0.170	0.369
	0	2.23 ± 1.60	-	2.45 ± 1.42	-	0.540
	4	1.94 ± 1.16	1.000	1.94 ± 0.86	0.106	0.801
Abdominal pain	-2	2.27 ± 1.29	0.168	2.33 ± 1.12	0.058	0.658
	0	1.87 ± 0.86	-	1.77 ± 0.85	-	0.914
	4	1.59 ± 0.78	0.250	1.50 ± 0.40	0.223	0.805
Indigestion syndrome	-2	2.40 ± 1.04	0.615	2.54 ± 1.29	0.551	0.844
	0	2.30 ± 1.03	-	2.20 ± 0.86	-	1.000
	4	2.17 ± 1.22	0.201	1.94 ± 0.75	0.139	0.961
Diarrhea syndrome	-2	1.77 ± 1.05	0.750	1.71 ± 0.71	1.000	0.878
	0	1.61 ± 0.68	-	1.77 ± 0.75	-	0.661
	4	1.41 ± 0.49	0.098	1.71 ± 0.68	0.866	0.345
Constipation syndrome	-2	1.77 ± 1.05	0.341	1.71 ± 0.71	0.784	0.138
	0	1.61 ± 0.68	-	1.77 ± 0.75	-	0.254
	4	1.41 ± 0.49	0.134	1.71 ± 0.68	1.000	0.883

0 week: Baseline. Test¹: There is also no significantly different compared from gastrointestinal symptom rating scale score at week 0 (Wilcoxon’s signed rank test); Test²: There is no significant difference between the rikkunshito with or without plus proton-pump inhibitor (PPI) treatment at each period (Wilcoxon’s rank sum test).