Low-dose amitriptyline combined with proton pump inhibitor for functional chest pain

Figure 3 Symptom response rate (A) and Beck Depression Inventory scores (B) after treatment. A: The response rates in patients after treatment with rabeprazole + amitriptyline vs double-dose of rabeprazole on the per-protocol analysis are demonstrated. In this analysis, the difference of the response rate between both groups was statistically significant; B: The Beck Depression Inventory (BDI) scores after treatment with amitriptyline and rabeprazole vs double-dose of rabeprazole are represented. The overall mean difference of BDI scores after 8 wk of treatment was not significantly different between group A and group B (6.71 ± 1.99 vs 7.16 ± 1.89, respectively; P = 0.49).