Low-dose amitriptyline combined with proton pump inhibitor for functional chest pain

Table 2 Global symptom scores by follow-up time

Time	Group A	Group B	P value1
Week 0	5.85 (5.09-6.61)	6.10 (5.34-6.86)	0.642
Week 1	4.90 (4.14-5.66)	5.10 (4.34-5.86)	0.709
Week 2	3.94 (3.08-4.80)	3.90 (3.06-4.74)	0.948
Week 3	3.76 (2.86-4.66)	3.95 (3.10-4.80)	0.755
Week 4	3.82 (2.96-4.68)	3.90 (3.10-4.70)	0.889
Week 5	3.18 (2.38-3.98)	3.80 (3.05-4.55)	0.259
Week 6	3.00 (2.21-3.79)	3.95 (3.21-4.69)	0.084
Week 7	2.89 (2.12-3.65)	4.05 (3.33-4.77)	0.031
Week 8	2.47 (1.68-3.27)	4.37 (3.63-5.11)	0.001

Data are least square means (95%CI). Group A: rabeprazole + amitriptyline group vs Group B: double dose of proton pump inhibitor group.

¹P value < 0.006 is considered statistically significant after adjusting the significance level of 0.05 using Bonferroni correction method for multiple comparisons. The significant difference between two groups was found at week 8 only (P < 0.006).