Analysis of single nucleotide polymorphisms in the region of CLDN2-MORC4 in relation to inflammatory bowel disease

Table 5 Genotype-phenotype correlation between Claudin-2 marker (rs12014762) polymorphism and clinical characteristics of 677 patients with Crohn’s disease (all families)

rs12014762 Crohn’s disease	At least one C	T	P value
Sex
Male	265	47
Female	354	11
Age at diagnosis (yr)
Mean (SD)	24.48 (12.11)	24.36 (11.46)	0.90
Median (range)	22 (3-70)	22 (8-63)
Location at onset:	n = 583	n = 54
Pure colonic disease	78	6	0.64
Pure ileal disease	117	14	0.31
Ileocolonic disease	274	309	0.87
Any colonic disease	414	37	0.70
Any ileal disease	424	42	0.42
Upper digestive tract	118	12	0.73
Perineal disease	147	11	0.53
Granuloma	237/478	26/43	0.12
Penetrating disease	218/478	22/43	0.48
Strictures	221/478	15/43	0.15
Extra-digestive symptoms	190/619	15/58	0.44
Smoking habits	n = 505	n = 51
Non-smoker	272	21	0.08
Smoker	157	21	0.14
Ex-smoker	76	9	0.62