Analysis of single nucleotide polymorphisms in the region of CLDN2-MORC4 in relation to inflammatory bowel disease

Table 4 Inflammatory bowel disease-phenotypes were investigated by performing family-based and case-control approach in genetic association studies

	rs7620166 (CLDN1)		rs12014762 (CLDN2)		rs8629 (CLDN4)
		allelic OR (95%CI)	P value	allelic OR (95%CI)	P value	allelic OR (95%CI)	P value
IBD	Swedish case-control	1.33 (1.04-1.72)	0.025	1.39 (0.95-2.01)	0.083	1.21 (0.89-1.65)	0.225
	Non-Swedish families	0.87 (0.72-1.06)	0.177	1.25 (0.89-1.77)	0.195	1.09 (0.88-1.33)	0.432
CD	Swedish case-control	1.17 (0.86-1.60)	0.319	1.98 (1.17-3.35)	0.007	1.25 (0.84-1.85)	0.258
	Non-Swedish families	0.80 (0.64-1.00)	0.052	1.37 (0.91-2.07)	0.126	1.14 (0.89-1.46)	0.287
UC	Swedish case-control	1.35 (0.98-1.84)	0.064	1.27 (0.80-2.02)	0.304	1.18 (0.80-1.73)	0.409
	Non-Swedish families	1.19 (0.77-1.84)	0.436	0.91 (0.39-2.14)	0.827	1.15 (0.75-1.77)	0.512

The family-based association studies included a total of 463 families. For the single nucleotide polymorphism -markers rs7620166 [claudin (CLDN)1], rs12014762 (CLDN2) and rs8629 (CLDN4) genotyping failed for 5 [including 2 Crohn’s disease (CD)], 9 (including 3 CD) and 7 (including 2 CD) samples, respectively. Results were based on 191, 103 and 102 cases of inflammatory bowel disease (IBD), CD and ulcerative colitis (UC), respectively and 333 controls. OR (and its associated 95%CI) and P values (based on log likelihood ratio χ² statistics) were calculated for the T allele of rs7620166, the C allele of rs12014762, and the C allele of rs8629.