Role of surgical resection for multiple hepatocellular carcinomas

Table 3 Prognostic factors for overall survival in surgical resection patients

Variable	Patients(n = 36)	1-yr OS	3-yr OS	5-yr OS	P value
Age (yr)					0.146
≤ 60	27	88.9%	81.5%	42.3%
> 60	9	100%	88.9%	66.7%
Gender					0.245
Male	34	91.2%	82.4%	45.1%
Female	2	100%	100%	100%
Serum albumin (g/dL)					0.642
≤ 3.5	10	90.0%	60.0%	48.0%
> 3.5	26	92.3%	87.7%	46.1%
ALT (IU/L)					0.593
≤ 50	27	92.6%	81.5%	53.7%
> 50	9	88.9%	71.1%	23.7%
AST (IU/L)					0.87
≤ 50	31	90.3%	80.6%	52.4%
> 50	5	100%	100%	50.0%
ICG R 15 (%)					0.992
≤ 14	25	92.0%	84.0%	47.1%
> 14	9	88.9%	77.8%	58.3%
α-fetoprotein					0.471
≤ 1000 IU/mL	32	90.6%	81.3%	47.3%
> 1000 IU/mL	4	100%	100%	50.0%
Cirrhosis					0.023
No	16	100%	93.8%	69.9%
Yes	20	85.0%	75.0%	26.5%
Main tumor size (cm)					0.629
< 3.0	17	94.1%	86.3%	43.1%
≥ 3.0	19	89.5%	73.7%	52.6%
Number of tumors					0.061
2	31	90.3%	80.6%	40.7%
3	5	100%	100%	100%
Lobar distribution of tumors					0.892
One lobes	24	91.7%	83.3%	49.4%
Two lobe	12	91.7%	83.3%	48.6%
Operation type					0.568
En bloc resection	23	91.3%	82.6%	43.4%
Multiple resection or combined with RFA	13	92.3%	84.6%	57.1%

OS: Overall survival; RFA: Radiofrequency ablation; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ICG R 15: Indocyanine green retention rate at 15.