Diagnostic value of AFP-L3 and PIVKA-II in hepatocellular carcinoma according to total-AFP

Table 3 Sensitivity of α-fetoprotein-L3 and prothrombin induced by vitamin K absence-II according to the tumor characteristics in 38 hepatocellular carcinoma patients with α-fetoprotein < 20 ng/mL n (%)

	n	AFP-L3	PIVKA-II	AFP-L3 and PIVKA-II combined
		(> 5%)	(> 40 AU/L)	(> 5%, > 40 AU/L)
Tumor stage (UICC)
I	11	7 (63.6)	5 (45.5)	9 (81.8)
II	16	12 (75.0)	9 (56.3)	16 (100)
III	9	6 (66.7)	6 (66.7)	8 (88.9)
IVa	2	2 (100)	2 (100)	2 (100)
Tumor size
< 2 cm	15	7 (46.7)	6 (40.0)	13 (86.7)
2-5 cm	17	8 (47.1)	11 (64.7)	16 (94.1)
> 5 cm	6	3 (50.0)	5 (83.3)	6 (100)
Tumor number
Single	24	16 (66.7)	12 (50.0)	22 (91.7)
Multiple	14	11 (78.6)	10 (71.4)	13 (92.7)

AFP: α-fetoprotein; PIVKA-II: Prothrombin induced by vitamin K absence-II; UICC: International Union Against Cancer; HCC: Hepatocellular carcinoma.