Diagnostic value of AFP-L3 and PIVKA-II in hepatocellular carcinoma according to total-AFP

Table 2 Performance of α-fetoprotein, α-fetoprotein-L3 and prothrombin induced by vitamin K absence-II in detecting hepatocellular carcinoma in all patients and in subgroups according to total α-fetoprotein levels: Total α-fetoprotein

		Cut-off value	Sensitivity	Specificity
Entire group (n = 168, 90 HCC)	AFP	10 ng/mL	78.9%	84.6%
	AFP-L3	5%	82.2%	79.5%
		10%	67.8%	93.6%
	PIVKA-II	40 AU/L	62.2%	94.9%
	AFP-L3 or PIVKA-II	5% or 40 AU/L	94.4%	75.6%
		10% or 40 AU/L	84.4%	89.7%
AFP < 20 ng/mL (n = 112, 38 HCC)	AFP-L3	5%	71.1%	83.8%
		10%	47.4%	97.3%
	PIVKA-II	40 AU/L	57.9%	95.9%
	AFP-L3 or PIVKA-II	5% or 40 AU/L	92.1%	79.7%
		10% or 40 AU/L	78.9%	93.2%
AFP < 200 ng/mL (n = 136, 58 HCC)	AFP-L3	5%	74.1%	79.5%
		10%	56.9%	93.6%
	PIVKA-II	40 AU/L	62.1%	94.9%
	AFP-L3 or PIVKA-II	5% or 40 AU/L	93.1%	75.6%
		10% or 40 AU/L	82.8%	89.7%

AFP: α-fetoprotein; PIVKA-II: Prothrombin induced by vitamin K absence-II; HCC: Hepatocellular carcinoma.