Clinicopathological characteristics in the differential diagnosis of hepatoid adenocarcinoma: A literature review

Table 2 Immunohistochemical staining characteristics of patients with hepatoid adenocarcinoma in the literature review n (%)

	Number	AFP	Hep Par1	CEA	CK18	CK19	CK20	CK7	AE1/AE3	α1-AT	CD10	GPC3
Total	217 (100)	177 (91.6)	24 (38.1)	37 (78.7)	22 (100)	27 (100)	6 (28.6)	4 (15.4)	12 (92.3)	10 (91)	5 (62.5)	10 (100)
Stomach	182 (83.9)	156 (90.6)	12 (26.7)	27 (75.0)	17 (100)	16 (100)	5 (38.5)	0 (0)	10 (100)	7 (87.5)	0 (0)	10 (100)
Gallbladder	8 (3.7)	5 (83.3)	4 (66.7)	3 (75)	1 (100)	6 (100)	0 (0)	2 (33.3)	1 (100)	1 (100)	3 (100)	NA
Uterus	7 (3.2)	6 (85.7)	NA	1 (100)	NA	NA	NA	NA	NA	NA	1 (100)	NA
Lung	5 (2.3)	4 (100)	0 (0)	1 (100)	1 (100)	1 (100)	1 (50)	2 (0)	NA	NA	1 (100)	NA
Urinary bladder	4 (1.8)	4 (100)	4 (100)	4 (100)	NA	NA	NA	NA	NA	NA	NA	NA
Esophagus	2 (0.9)	2 (100)	1 (50)	NA	NA	NA	NA	NA	NA	2 (100)	NA	NA
Peritoneum	2 (0.9)	1 (50)	1 (100)	NA	1 (100)	NA	0 (0)	NA	1 (50)	NA	NA	NA
Retroperitoneum	1 (< 0.5)	NA	NA	NA	NA	NA	NA	NA	0 (0)	NA	NA	NA
Testis	1 (< 0.5)	1 (100)	0 (0)	NA	NA	NA	NA	NA	NA	NA	NA	NA
Ovary	1 (< 0.5)	1 (100)	NA	1 (100)	NA	NA	NA	NA	NA	NA	NA	NA
Jejunum	1 (< 0.5)	1 (100)	1 (100)	NA	1 (100)	1 (100)	0 (0)	0 (0)	NA	NA	NA	NA
Transverse colon	1 (< 0.5)	NA	NA	NA	NA	1 (100)	NA	NA	NA	NA	NA	NA
Rectum	1 (< 0.5)	1 (100)	1 (100)	NA	1 (100)	1 (100)	0 (0)	0 (0)	NA	NA	NA	NA
Ureter	1 (< 0.5)	1 (100)	NA	NA	NA	1 (100)	0 (0)	NA	NA	NA	0 (0)	NA

CEA: Carcinoembryonic antigen; CK: Cytokeratin; AE1/AE3: Anti-pancytokeratin AE1/AE3; CD10: Cluster of differentiation 10; α1-AT: α1-Antitrypsin; GPC-3: Glypican 3; AFP: α-fetoprotein; NA: Not available.