Strategies to rescue steatotic livers before transplantation in clinical and experimental studies

Table 1 Intrinsic composition of preservation solutions in this review

		UW	HTK	Celsior	IGL-1	UW-gluconate	Kreb-Henseleit	MEM
Electrolyte	Na	25	15	100	125	125	143	143.4
(mmol/L)	K	120	9	15	30	25	5.9	5.4
	Mg	5	4	13	5	5	1.2	0.8
	Ca		0.0015	0.25		0.5	1.25	1.4
	Cl	20	32	42		1	125.2	124
	SO4	5			5		1.2	0.8
Buffer	Phosphate	25			25	15	1.2	1
(mmol/L)	Bicarbonate					25	25	26.2
	HEPES					10	20
	Histidine		198	30				0.27
Antioxidant	Glutathione	3		3	3	3
(mmol/L)	Allopurinol	1			1	1
	Mannitol		38	60
	NAC						5
	Vit C							0.25
	Glucose					10	5	5.5
Metabolic Substrates	Adenosine	5			5	5
(mmol/L)	Adenine					5
	Ribose					5
	Tryptophan		2
	Ketoglutarate		1
	Glutamate			20
	Amino acid							0.7
Impermeants	Lactobionate	100		80	100
(mmol/L)	Gluconate					95
	Raffinose	30			30	30
Colloid	HES	50
(g/L)	PEG				1	50
Other intrinsic compounds	Insulin	100 U
	Dexamethason	8 mg
	Penicillin	40 U
	Phenol-red (mmol/L)							0.03
Osmolarity		340	300	363	330	360	320	310

UW: University of Wisconsin; HTK: Histidine-trypotphan-ketoglutarate; IGL-1: Institut Georges Lopez-1; MEM: Minimum essential cell culture medium; HEPES: N-2-hydroxyethyl-piperazine-N-2-ethanesulfonic acid; NAC: N-acetylcysteine; HES: Hydroxyethyl starch; PEG: Polyethylene glycol.