Influence of up-regulation of Notch ligand DLL4 on biological behaviors of human gastric cancer cells

Figure 5 Up-regulation of Delta-like ligand 4 promoted tumorigenesis of SGC7901 cells in vivo. Twenty-four 4-wk-old male BALB/c nu/nu mice were divided randomly into three groups and implanted subcutaneously with control/SGC7901-vector/SGC7901-Delta-like ligand 4 (DLL4) cells. A: Six weeks after inoculation, the size of subcutaneous formed tumor masses of the SGC7901-DLL4 group (2640.5 ± 923.6 mm³) was significantly larger than the control (1011.1 ± 273.6 mm³) and SGC7901-vector groups (1115.1 ± 223.8 mm³); B: Immunohistochemistry staining of DLL4 confirmed the up-regulation of DLL4 in the SGC7901-DLL4 group. ^aP < 0.05 vs the SGC7901-vector group.