First-line erlotinib and fixed dose-rate gemcitabine for advanced pancreatic cancer

Table 3 Toxicity (maximum toxicity per patient) n (%)

Variables	Grade 0	Grade 1	Grade 2	Grade 3	Grade 4
Haemoglobin	15 (32.6)	17 (37.0)	10 (21.7)	4 (8.7)	-
Leucopenia	29 (63.0)	3 (6.5)	9 (19.6)	5 (10.9)	-
Neutropenia	25 (54.3)	2 (4.3)	9 (19.6)	8 (17.4)	2 (4.3)
Febrile neutropenia	44 (95.7)	-	2 (4.3)	-	-
Platelet	32 (69.6)	6 (13.0)	2 (4.3)	6 (13.0)	-
Fever	35 (76.1)	9 (19.6)	2 (4.3)	-	-
Bleeding	45 (97.8)	-	-	1 (2.2)	-
Alopecia	41 (89.1)	4 (8.7)	1 (2.2)	-	-
Anorexia	38 (82.6)	7 (15.2)	1 (2.2)	-	-
Asthenia	22 (47.8)	12 (26.1)	11 (23.9)	1 (2.2)	-
Cardiac	45 (97.8)	-	1 (2.2)	-	-
Skin	24 (52.2)	15 (32.6)	5 (10.9)	2 (4.3)	-
Diarrhoea	18 (39.1)	16 (34.8)	11 (23.9)	1 (2.2)	-
Constipation	46 (100.0)	-	-	-	-
Stomatitis	42 (91.3)	1 (2.2)	3 (6.5)	-	-
ALT	24 (52.2)	13 (28.3)	6 (13.0)	3 (6.5)	-
AST	19 (41.3)	12 (26.1)	10 (21.7)	4 (8.7)	1 (2.2)
Bilirubine	42 (91.3)	2 (4.3)	2 (4.3)	-	-
Renal	43 (93.5)	3 (6.5)	-	-	-
Neurological	45 (97.8)	1 (2.2)	-	-	-
Nausea	39 (84.8)	3 (6.5)	4 (8.7)	-	-
Vomiting	40 (87.0)	3 (6.5)	3 (6.5)	-	-

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase.