Underexpression of LATS1 TSG in colorectal cancer is associated with promoter hypermethylation

Figure 2 Microsatellite instability status and large tumor suppressor 1 expression. Comparison of large tumor suppressor 1 (LATS1) mRNA levels in cases divided by the mutations observed in the BAT26, BAT25, and BAT40 microsatellite markers. Samples were considered to have microsatellite stability (MSS; no mutation), microsatellite instability-low grade (MSI-L; 1-2 mutations, light grey box), and microsatellite instability-high grade (MSI-H; mutations in all three markers, dark grey box). MSS (n = 40), MSI-L (n = 30), MSI-H (n = 14). Vertical bars represent LATS1 fold ratio calibrated to the average C_t of MSS cases - (ΔΔC_t^LATS1 = ΔC_t^{LATS1, MSI} - ΔC_t^{LATS1, MSS}), error bars: SE.