Underexpression of LATS1 TSG in colorectal cancer is associated with promoter hypermethylation

doi:10.3748/wjg.v19.i27.4363

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 19, Issue 27

This Article

Academic Content and Language Evaluation of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (7551)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-4) series, Tables (1-2) series.

Item

Count

PDF

392

HTML

4729

Figures (1-4)

264

Tables (1-2)

269

Sum=5654

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

1070

Download

827

Sum=1897

Jul 21, 2013 (publication date) through Feb 6, 2025

Times Cited of This Article

Times Cited (43)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Brief Article

World J Gastroenterol. Jul 21, 2013; 19(27): 4363-4373
Published online Jul 21, 2013. doi: 10.3748/wjg.v19.i27.4363

Table 2 Relationship between large tumor suppressor 1 promoter methylation status, large tumor suppressor 1 mRNA level, and histopathological and microsatellite instability data in colorectal cancer n (%)

Clinical parameter		Total	M	*Av. LATS1* mRNA fold**	UM	*Av. LATS1* mRNA fold**	*Av. LATS1* mRNA fold**	P value between
				change, control vs M		change, control vs UM	change, UM vs M	UM and M groups
Tumor total		44	25 (57)	597	19	3.55	162	0.00005
Dukes’ stage	A	4	4 (100)	556	0	No data	No data	-
	B	16	5 (31)	699	11	228	3	0.041
	C	19	11 (58)	469	8	1.53	305	0.009
	D	5	5 (100)	1263	0	No data	No data	-
Lymph node metastasis	Negative	20	9 (45)	632	11	75	8	0.015
Lymph node metastasis	Positive	24	16 (67)	586	8	1.53	381	0.0002
Histological differentiation G stage	G1	2	1 (50)	801	1	538	1.5	NS
	G2	11	3 (27)	1216	8	1.5	802	0.018
	G3	28	20 (71)	538	8	166	3.65	0.015
	G4	3	1 (33)	699	2	92	8	NS
MSI status	MSS	27	19 (70)	7	8	1.7	4	NS
	MSI-L	11	7 (64)	8	4	2.4	3.3	NS
	MSI-H	6	4 (67)	12	2	3.5	3.4	NS

M: Hypermethylation of large tumor suppressor 1 (LATS1) promoter; UM: Unmethylation of LATS1 promoter; MSI: Microsatellite instability; MSS: Microsatellite stable; MSI-L: Low grade MSI, mutation in 1-2 BAT markers; MSI-H: High grade MSI, mutation in 3 BAT markers; NS: Noy significant.

Citation: Wierzbicki PM, Adrych K, Kartanowicz D, Stanislawowski M, Kowalczyk A, Godlewski J, Skwierz-Bogdanska I, Celinski K, Gach T, Kulig J, Korybalski B, Kmiec Z. Underexpression of LATS1 TSG in colorectal cancer is associated with promoter hypermethylation. World J Gastroenterol 2013; 19(27): 4363-4373
URL: https://www.wjgnet.com/1007-9327/full/v19/i27/4363.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i27.4363