Underexpression of LATS1 TSG in colorectal cancer is associated with promoter hypermethylation

doi:10.3748/wjg.v19.i27.4363

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World Journal of Gastroenterology

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 21, 2013; 19(27): 4363-4373
Published online Jul 21, 2013. doi: 10.3748/wjg.v19.i27.4363

Table 2 Relationship between large tumor suppressor 1 promoter methylation status, large tumor suppressor 1 mRNA level, and histopathological and microsatellite instability data in colorectal cancer n (%)

Clinical parameter		Total	M	*Av. LATS1* mRNA fold**	UM	*Av. LATS1* mRNA fold**	*Av. LATS1* mRNA fold**	P value between
				change, control vs M		change, control vs UM	change, UM vs M	UM and M groups
Tumor total		44	25 (57)	597	19	3.55	162	0.00005
Dukes’ stage	A	4	4 (100)	556	0	No data	No data	-
	B	16	5 (31)	699	11	228	3	0.041
	C	19	11 (58)	469	8	1.53	305	0.009
	D	5	5 (100)	1263	0	No data	No data	-
Lymph node metastasis	Negative	20	9 (45)	632	11	75	8	0.015
Lymph node metastasis	Positive	24	16 (67)	586	8	1.53	381	0.0002
Histological differentiation G stage	G1	2	1 (50)	801	1	538	1.5	NS
	G2	11	3 (27)	1216	8	1.5	802	0.018
	G3	28	20 (71)	538	8	166	3.65	0.015
	G4	3	1 (33)	699	2	92	8	NS
MSI status	MSS	27	19 (70)	7	8	1.7	4	NS
	MSI-L	11	7 (64)	8	4	2.4	3.3	NS
	MSI-H	6	4 (67)	12	2	3.5	3.4	NS

M: Hypermethylation of large tumor suppressor 1 (LATS1) promoter; UM: Unmethylation of LATS1 promoter; MSI: Microsatellite instability; MSS: Microsatellite stable; MSI-L: Low grade MSI, mutation in 1-2 BAT markers; MSI-H: High grade MSI, mutation in 3 BAT markers; NS: Noy significant.

Citation: Wierzbicki PM, Adrych K, Kartanowicz D, Stanislawowski M, Kowalczyk A, Godlewski J, Skwierz-Bogdanska I, Celinski K, Gach T, Kulig J, Korybalski B, Kmiec Z. Underexpression of LATS1 TSG in colorectal cancer is associated with promoter hypermethylation. World J Gastroenterol 2013; 19(27): 4363-4373
URL: https://www.wjgnet.com/1007-9327/full/v19/i27/4363.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i27.4363