Effect of amitriptyline on gastrointestinal function and brain-gut peptides: A double-blind trial

Table 2 Effects of amitriptyline on gastrointestinal function and brain-gut peptides

Variable	Amitriptyline (n = 28)	Placebo (n = 28)	P value
Cross-sectional area of the proximal stomach (cm2)
200 mL	16.51 ± 3.78	16.56 ± 3.98	0.97
400 mL	27.14 ± 5.71	27.84 ± 5.95	0.49
600 mL	34.11 ± 6.11	34.85 ± 6.61	0.39
800 mL	39.58 ± 7.35	40.86 ± 8.45	0.34
Difficulty in drinking water VAS
200 mL	0.93 ± 0.65	0.96 ± 0.56	0.58
400 mL	1.93 ± 0.46	1.82 ± 0.54	0.29
600 mL	2.98 ± 0.85	3.57 ± 0.94	0.001
800 mL	4.57 ± 0.98	5.57 ± 0.82	0.001
Gastric emptying
5 min	78.40 ± 11.71	78.84 ± 7.47	0.87
10 min	66.72 ± 11.63	64.54 ± 10.29	0.47
OCTT (min)	109.29 ± 29.68	96.61 ± 23.9	0.004
Plasma levels (pg/mL)
MTL	461.88 ± 129.66	473.40 ± 122.75	0.61
Ghrelin	526.87 ± 158.44	442.87 ± 176.79	0.04
NPY	965.64 ± 165.63	890.15 ± 131.46	0.03

Values are represented as mean ± SD. Symptom scores on 10-cm visual analogue scale. OCTT: Orocecal transit time; MTL: Motilin; NPY: Neuropeptide Y; VAS: Visual analogue scale.