Metabonomic studies of pancreatic cancer response to radiotherapy in a mouse xenograft model using magnetic resonance spectroscopy and principal components analysis

Table 1 Relative integrals and their ratios from some selected metabolites contributing to the classification of normal pancreas and pancreatic tumor tissues

		Normal pancreas	Pancreatic tumor	P-value
Metabolites	Choline	2.75 ± 1.37	3.99 ± 0.35	0.0376
	Taurine	1.99 ± 0.55	13.63 ± 2.92	0.0001
	Betaine	2.91 ± 0.57	1.58 ± 0.47	0.0002
	Glutamic acid	0.29 ± 0.11	0.46 ± 0.13	0.0260
	Alanine	0.60 ± 0.14	1.93 ± 0.16	0.0001
	Lactate	1.93 ± 0.86	8.30 ± 1.02	0.0001
	Acetic acid	0.06 ± 0.10	0.06 ± 0.03	0.7942
	Glycerophosphocholine+ phosphocholine	19.47 ± 1.36	16.61 ± 1.31	0.0007
Metabolites ratio	Glycerophosphocholine/Creatine	3.51 ± 0.76	2.35 ± 0.58	0.0042
	Phosphocholine/Creatine	5.19 ± 0.96	6.22 ± 1.52	0.1284