Polydatin attenuated food allergy via store-operated calcium channels in mast cell

Figure 6 Polydatin reduced Ca²⁺ entry through store-operated calcium channels in food allergic mast cells. Typical responses of thapsigargin (TG)-evoked Ca²⁺ entry through store-operated calcium channels in rat peritoneal mast cells (RPMCs). A: Phosphate-buffered saline (PBS) group; B: Ovalbumin (OVA) group; C: OVA + polydatin (PD) group; D: PD group; E: Averaged peak amplitude of Ca²⁺ entry (second peak) as recorded in each group. ^bP < 0.01 vs PBS group; ^dP < 0.01 vs OVA group. RPMCs were isolated from Brown-Norway rat treated with or without PD. Intracellular Ca²⁺ was indicated by a fluo-4 fluorescent probe. Total cell numbers are 40-50 for each group, and the cells were from four independent experiments.