Roles of BN52021 in platelet-activating factor pathway in inflammatory MS1 cells

Figure 3 The effect of BN52021 on platelet-activating factor receptor signaling molecules at the mRNA level under lipopolysaccharide-induced inflammation. The mRNA level of adenylate cyclase (AC) (A), G protein-coupled receptor kinases (GRK) (B), phospholipase A₂ (PLA₂) (C), phospholipase Cβ (PLCβ) (D), p38-mitogen-activated protein kinase (p38 MAPK) (E) and protein tyrosine kinase (PTK) (F) was up-regulated after lipopolysaccharide (LPS) stimulation. The up-regulation of AC, GRK, p38 MAPK, PLCβ and PLA₂ mRNA was significantly suppressed by BN52021 except for that of PTK. ^aP < 0.05 vs control; ^dP < 0.01 vs the LPS + dimethyl sulfoxide (DMSO) groups.