CYP1A1, GSTM1, GSTT1 and NQO1 polymorphisms and colorectal adenomas in Japanese men

Table 5 Associations between combinations of genetic polymorphisms and colorectal adenomas with stratification by smoking category

Genotype 1	Genotype 2	< 20 pack-years		≥20 pack-years		Interaction (P)
		n1	OR (95%CI)2	n1	OR (95%CI)2
CYP1A1*2A	GSTM1					0.44
03	Non-null	25/87	1.00 (referent)	50/95	1.78 (1.00-3.14)
0	Null	34/120	0.94 (0.52-1.69)	65/86	2.53 (1.45-4.43)
≥ 1	Non-null	44/177	0.86 (0.49-1.50)	81/147	1.82 (1.07-3.10)
≥ 1	Null	56/169	1.19 (0.69-2.05)	100/171	1.92 (1.14-3.22)
CYP1A1*2A	GSTT1					0.56
03	Non-null	29/98	1.00 (referent)	63/112	1.94 (1.15-3.28)
0	Null	30/109	0.95 (0.53-1.71)	52/69	2.53 (1.44-4.44)
≥ 1	Non-null	60/170	1.26 (0.75-2.11)	106/172	2.07 (1.27-3.39)
≥ 1	Null	40/176	0.81 (0.47-1.40)	75/146	1.70 (1.02-2.82)
CYP1A1*2A	GSTM1 + GSTT1					0.40
03	04	14/42	1.00 (referent)	27/60	1.34 (0.62-2.89)
0	1	26/101	0.76 (0.36-1.62)	59/87	2.02 (1.00-4.07)
0	2 (both null)	19/64	0.87 (0.39-1.94)	29/34	2.46 (1.11-5.46)
≥ 1	0	25/92	0.83 (0.39-1.78)	52/79	1.89 (0.93-3.86)
≥ 1	1	54/163	1.01 (0.51-2.01)	83/161	1.52 (0.78-2.98)
≥ 1	2 (both null)	21/91	0.73 (0.33-1.59)	46/78	1.66 (0.81-3.40)
CYP1A1*2A	NQO1 C609T					0.76
03	CC	20/73	1.00 (referent)	43/60	2.55 (1.34-4.86)
0	CT + TT	39/134	1.04 (0.56-1.94)	72/121	2.15 (1.20-3.86)
≥ 1	CC	32/148	0.81 (0.43-1.54)	66/131	1.69 (0.94-3.04)
≥ 1	CT + TT	68/198	1.29 (0.72-2.29)	115/187	2.23 (1.28-3.89)
CYP1A1*2C	GSTM1					0.78
02	Non-null	47/150	1.00 (referent)	80/144	1.74 (1.13-2.69)
0	Null	59/179	1.04 (0.67-1.63)	95/138	2.15 (1.40-3.31)
≥ 1	Non-null	22/114	0.63 (0.36-1.11)	51/98	1.59 (0.98-2.57)
≥ 1	Null	31/110	0.94 (0.55-1.58)	70/119	1.77 (1.13-2.78)
CYP1A1*2C	GSTT1					0.11
02	Non-null	60/151	1.00 (referent)	94/170	1.39 (0.93-2.07)
0	Null	46/178	0.66 (0.42-1.03)	81/112	1.80 (1.18-2.75)
≥ 1	Non-null	29/117	0.65 (0.39-1.09)	75/114	1.62 (1.06-2.48)
≥ 1	Null	24/107	0.59 (0.34-1.01)	46/103	1.06 (0.66-1.69)
CYP1A1*2C	GSTM1 + GSTT1					0.22
02	04	29/71	1.00 (referent)	45/85	1.26 (0.71-2.23)
0	1	49/159	0.73 (0.42-1.26)	84/144	1.41 (0.84-2.37)
0	2 (both null)	28/99	0.69 (0.38-1.28)	46/53	2.03 (1.12-3.69)
≥ 1	0	10/63	0.39 (0.17-0.87)	34/54	1.46 (0.79-2.72)
≥ 1	1	31/105	0.75 (0.41-1.36)	58/104	1.31 (0.76-2.26)
≥ 1	2 (both null)	12/56	0.53 (0.25-1.15)	29/59	1.09 (0.58-2.05)
CYP1A1*2C	NQO1 C609T					0.34
02	CC	34/127	1.00 (referent)	68/93	2.64 (1.60-4.36)
0	CT + TT	72/202	1.33 (0.83-2.12)	107/189	2.10 (1.33-3.31)
≥ 1	CC	18/94	0.75 (0.39-1.41)	41/98	1.41 (0.83-2.41)
≥ 1	CT + TT	35/130	1.03 (0.60-1.77)	80/119	2.47 (1.53-4.00)

¹Number of cases/controls;

²Adjusted for age, hospital, rank in the Self-Defense Forces, body mass index, cigarette smoking, alcohol use, leisure-time physical activity and parental history of colorectal cancer;

³Number of variant alleles;

⁴Number of null genotypes.