CYP1A1, GSTM1, GSTT1 and NQO1 polymorphisms and colorectal adenomas in Japanese men

Table 3 Associations between combinations of genetic polymorphisms and colorectal adenomas

Genotype 1	Genotype 2	n1	OR (95%CI)2	Interaction (P)
CYP1A1*2A	GSTM1			0.94
03	Non-null	75/182	1.00 (referent)
0	Null	99/206	1.20 (0.83-1.74)
≥ 1	Non-null	125/324	0.96 (0.67-1.35)
≥ 1	Null	156/340	1.12 (0.80-1.58)
CYP1A1*2A	GSTT1			0.08
03	Non-null	92/210	1.00 (referent)
0	Null	82/178	1.14 (0.79-1.65)
≥ 1	Non-null	166/342	1.15 (0.83-1.58)
≥ 1	Null	115/322	0.85 (0.61-1.19)
CYP1A1*2A	GSTM1 + GSTT1			0.44
03	04	41/102	1.00 (referent)
0	1	85/188	1.19 (0.75-1.88)
0	2 (both null)	48/98	1.35 (0.81-2.27)
≥ 1	0	77/171	1.17 (0.74-1.86)
≥ 1	1	137/324	1.12 (0.73-1.72)
≥ 1	2 (both null)	67/169	1.03 (0.64-1.66)
CYP1A1*2A	NQO1 C609T			0.09
03	CC	63/133	1.00 (referent)
0	CT + TT	111/255	0.92 (0.63-1.36)
≥ 1	CC	98/279	0.73 (0.49-1.07)
≥ 1	CT + TT	183/385	1.02 (0.71-1.47)
CYP1A1*2C	GSTM1			0.77
03	Non-null	127/294	1.00 (referent)
0	Null	154/317	1.16 (0.86-1.55)
≥ 1	Non-null	73/212	0.79 (0.56-1.12)
≥ 1	Null	101/229	0.98 (0.71-1.36)
CYP1A1*2C	GSTT1			0.24
03	Non-null	154/321	1.00 (referent)
0	Null	127/290	0.97 (0.73-1.31)
≥ 1	Non-null	104/231	0.93 (0.68-1.27)
≥ 1	Null	70/210	0.69 (0.49-0.97)
CYP1A1*2C	GSTM1 + GSTT1			0.37
03	4	74/156	1.00 (referent)
0	1	133/303	0.96 (0.67-1.37)
0	2 (both null)	74/152	1.13 (0.75-1.69)
≥ 1	0	44/117	0.79 (0.50-1.25)
≥ 1	1	89/209	0.92 (0.63-1.35)
≥ 1	2 (both null)	41/115	0.72 (0.45-1.15)
CYP1A1*2C	NQO1 C609T			0.05
03	CC	102/220	1.00 (referent)
0	CT + TT	179/391	0.99 (0.73-1.34)
≥ 1	CC	59/192	0.61 (0.42-0.91)
≥ 1	CT + TT	115/249	0.98 (0.71-1.37)

¹Number of cases/controls;

²Adjusted for age, hospital, rank in the Self-Defense Forces, body mass index, cigarette smoking, alcohol use, leisure-time physical activity and parental history of colorectal cancer;

³Number of variant alleles;

⁴Number of null genotypes.