Differential mucin phenotypes and their significance in a variation of colorectal carcinoma

Table 4 Prognostic significance of clinicopathologic variables in well-to-moderately differentiated adenocarcinoma and poorly differentiated adenocarcinoma

	Recurrence/metastasis				Death
	Parameter		HR (95%CI)	P value	Parameter		HR (95%CI)	P value
WMDA	Univariate analysis				Univariate analysis
		Age (over 65 yr)	2.215 (0.974-5.037)	0.058		Age (over 65 yr)	1.984 (0.794-4.955)	0.142
		Gender (male)	0.887 (0.398-1.975)	0.769		Gender (male)	2.194 (0.727-6.617)	0.163
		Location (right-sided)	1.268 (0.559-2.875)	0.570		Location (right-sided)	1.335 (0.524-3.402)	0.545
		TNM stage (III/IV)	3.642 (1.446-9.170)	0.006		TNM stage (III/IV)	2.632 (0.990-6.996)	0.052
		MUC2 positive	0.477 (0.210-1.082)	0.077		MUC2 positive	0.527 (0.207-1.341)	0.179
		MUC5AC positive	1.389 (0.613-3.145)	0.431		MUC5AC positive	1.803 (0.723-4.497)	0.206
	Multivariate analysis				Multivariate analysis
		Age (over 65 yr)	2.220 (0.965-5.017)	0.061
		TNM stage (III/IV)	3.473 (1.370-8.805)	0.009
		MUC2 positive	0.554 (0.243-1.265)	0.161
PDA	Univariate analysis				Univariate analysis
		Age (over 65 yr)	0.891 (0.495-1.602)	0.700		Age (over 65 yr)	0.985 (0.955-1.016)	0.331
		Gender (male)	0.624 (0.343-1.138)	0.124		Gender (male)	0.899 (0.484-1.667)	0.734
		Location (right-sided)	0.857 (0.474-1.549)	0.609		Location (right-sided)	0.686 (0.371-1.270)	0.231
		TNM stage (III/IV)	2.647 (1.109-6.320)	0.028		TNM stage (III/IV)	3.208 (1.236-8.330)	0.017
		MUC2 positive	0.936 (0.368-2.379)	0.890		MUC2 positive	1.009 (0.357-2.850)	0.987
		MUC5AC positive	0.433 (0.237-0.793)	0.007		MUC5AC positive	0.599 (0.323-1.112)	0.105
		dMMR	0.373 (0.164-0.847)	0.018		dMMR	0.352 (0.153-0.810)	0.014
	Multivariate analysis				Multivariate analysis
		TNM stage (III/IV)	1.698 (0.672-4.289)	0.263		TNM stage (III/IV)	2.385 (0.886-6.421)	0.085
		MUC5AC positive	0.586 (0.307-1.117)	0.104		dMMR	0.466 (0.195-1.111)	0.085
		dMMR	0.228 (0.260-1.308)	0.175

WMDA: Well-to-moderately differentiated adenocarcinoma; PDA: Poorly differentiated adenocarcinoma; dMMR: Mismatch-repair deficiency; TNM: Tumor node metastasis; MUC: Mucin.