Differential mucin phenotypes and their significance in a variation of colorectal carcinoma

Table 3 Expression of the mucin core proteins and clinicopathologic variables n (%)

		WMDA			PDA			MUA
		MUC2			MUC2			MUC2
		-	+	P value	-	+	P value	-	+	P value
Median age (range), yr		64 (32-82)	64 (34-87)	0.783	64 (35-92)	66.5 (55-86)	0.633	65 (52-88)	71 (26-90)	0.842
Gender	Male	21 (33.3)	18 (28.6)	0.537	41 (45.1)	4 (4.4)	1.000	1 (1.2)	45 (55.6)	0.311
	Female	11 (17.5)	13 (20.6)		42 (46.1)	4 (4.4)		3 (3.7)	32 (39.5)
Locus	Right-sided	10 (15.9)	10 (15.9)	0.932	47 (51.6)	6 (6.6)	0.461	1 (1.2)	40 (49.4)	0.359
	Left-sided	22 (34.9)	21 (33.3)		36 (39.6)	2 (2.2)		3 (3.7)	37 (45.7)
Venous invasion	Yes	24 (38.1)	24 (38.1)	1.000	71 (79.0)	6 (6.6)	0.325	3 (3.7)	38 (46.9)	0.616
	No	8 (12.7)	7 (11.1)		11 (12.2)	2 (2.2)		1 (1.2)	39 (48.1)
Lymphatic invasion	Yes	21 (33.3)	14 (22.2)	0.102	76 (84.4)	6 (6.7)	0.148	1 (1.2)	51 (63.0)	1.000
	No	11 (17.5)	17 (27.0)		6 (6.7)	2 (2.2)		3 (3.7)	26 (32.1)
Nodal metastasis	Yes	20 (31.7)	14 (22.2)	0.167	64 (72.7)	5 (5.7)	0.362	2 (2.5)	35 (44.3)	1.000
	No	12 (19.0)	17 (27.0)		16 (18.2)	3 (3.4)		2 (2.5)	40 (50.6)
TNM stage	I/II	12 (19.0)	17 (27.0)	0.167	14 (15.6)	3 (3.3)	0.171	2 (2.5)	38 (48.1)	1.000
	III/IV	20 (31.7)	14 (22.2)		68 (75.5)	5 (5.6)		2 (2.5)	37 (46.8)
dMMR	Yes	ND			16 (17.6)	3 (3.3)	0.356	ND
	No				67 (73.6)	5 (5.5)
		MUC5AC			MUC5AC			MUC5AC
		-	+	P value	-	+	P value	-	+	P value
Median age (range), yr		64 (32-83)	69 (47-87)	0.099	63 (36-87)	70 (35-92)	0.096	67 (34-87)	72 (26-90)	0.061
Gender	Male	26 (41.3)	13 (20.6)	0.677	22 (24.2)	23 (25.3)	0.919	23 (28.4)	23 (28.4)	0.371
	Female	18 (28.6)	6 (9.5)		22 (24.2)	24 (26.3)		14 (17.3)	21 (25.9)
Locus	Right-sided	10 (15.9)	10 (15.9)	0.410	20 (22.0)	33 (36.3)	0.017	12 (14.8)	29 (35.8)	0.003
	Left-sided	34 (54.0)	9 (14.3)		24 (26.4)	14 (15.4)		25 (30.9)	15 (18.5)
Venous invasion	Yes	34 (54.0)	14 (22.2)	0.757	38 (42.2)	39 (43.3)	1.000	16 (19.8)	25 (30.9)	0.224
	No	10 (15.9)	5 (7.9)		6 (6.7)	7 (7.8)		21 (25.9)	19 (23.5)
Lymphatic invasion	Yes	26 (41.3)	9 (14.3)	0.560	41 (45.6)	41 (45.6)	0.714	25 (30.9)	29 (35.8)	0.875
	No	18 (28.6)	10 (15.9)		3 (3.3)	5 (5.6)		12 (14.8)	15 (18.5)
Nodal metastasis	Yes	23 (36.5)	11 (17.5)	0.892	40 (45.5)	29 (33.0)	0.010	17 (21.5)	20 (25.3)	0.950
	No	21 (33.3)	8 (12.7)		4 (4.5)	15 (17.0)		19 (24.1)	23 (29.1)
TNM stage	I/II	21 (33.3)	8 (12.7)	0.892	3 (3.3)	14 (15.6)	0.010	18 (22.8)	22 (27.8)	0.918
	III/IV	23 (36.5)	11 (17.5)		41 (45.6)	32 (35.6)		18 (22.8)	21 (26.6)
dMMR	Yes	ND			3 (3.3)	16 (17.6)	0.003	ND
	No				41 (45.1)	31 (34.1)

MUC: Mucin; WMDA: Well-to-moderately differentiated adenocarcinoma; PDA: Poorly differentiated adenocarcinoma; MUA: Mucinous adenocarcinoma; dMMR: Mismatch-repair deficiency; ND: Not determined; TNM: Tumor node metastasis.