Role of activin A in carbon tetrachloride-induced acute liver injury

Figure 5 Effects of anti-activin A antibody in vivo on serum alanine aminotransferase and aspartate aminotransferase levels and pathological change of liver in carbon tetrachloride-treated mouse. A: Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were detected in mouse 3 d after carbon tetrachloride (CCl₄) treatment. Immunoglobulin G (IgG) + Cont, IgG control group; Anti-A + Cont, anti-activin A control group; IgG + CCl₄, IgG plus CCl₄ group; Anti-A + CCl₄, anti-activin A plus CCl4 group. ^bP < 0.01 vs IgG + CCl₄ group; B: Pathological change of liver in mouse 3 d after CCl₄ treatment was analyzed by hematoxylin and eosin staining. Arrows represent lesion area (magnification × 40).