Mitochondrial ATP 6 and 8 polymorphisms in irritable bowel syndrome with diarrhea

Table 2 Summary of mitochondrial DNA mutations in the ATP 6 and 8 genes

Nucleotide position	Base change (N>T)	mtDNA region	Amino acid change
8392	G>A	ATP8	syn
8394	C>T	ATP8	Missense
8414	C>T	ATP8	Missense
8459	A>G	ATP8	Missense
8473	T>C	ATP8	syn
8563	A>G	ATP8 and ATP6	ATP6: missense;ATP8: syn
8584	G>A	ATP6	Missense
8684	C>T	ATP6	Missense
8697	G>A	ATP6	syn
8701	A>G	ATP6	Missense
8705	T>C	ATP6	Missense
8727	C>T	ATP6	syn
8772	T>C	ATP6	syn
8784	A>G	ATP6	syn
8793	T>C	ATP6	syn
8794	C>T	ATP6	Missense
8829	C>T	ATP6	syn
8856	G>A	ATP6	syn
8860	A>G	ATP6	Missense
8943	C>T	ATP6	syn
8994	G>A	ATP6	syn
9053	G>A	ATP6	Missense
9123	G>A	ATP6	syn
9128	T>C	ATP6	Missense
9180	A>G	ATP6	syn

mtDNA: Mitochondrial DNA; syn: Synonymous; N: Sequence obtained from National Center for Biotechnology Information genbank; T: Mutated sequence in the specimens; A: Adenine; T: Thymine; G: Guanine; C: Cytosine.